Plenhyage is an advanced polynucleotide (PN) skin booster from Italy designed to stimulate skin regeneration, repair damaged cells, and deliver deep hydration — all without changing facial volume or shape. Its main active ingredient is highly purified polynucleotides derived from salmon trout through a patented biotechnology process. Unlike dermal fillers, Plenhyage works by activating your skin’s own repair mechanisms, making it a regenerative treatment rather than a cosmetic one.
How Does Plenhyage Work?
Plenhyage delivers polynucleotides into the skin, where they stimulate fibroblasts — the cells responsible for producing collagen and elastin. This activation leads to increased collagen and elastin production for firmer, more resilient skin, repair of damaged skin cells and improvement in overall skin structure, deep hydration from within the dermis (not just the surface), and reduction in redness, inflammation, and signs of scarring.
The result is skin that looks healthier, feels firmer, and has a more even, natural glow — achieved through your body’s own regenerative processes.
Who Is Plenhyage Suitable For?
Plenhyage is suitable for patients with dull, uneven, or dehydrated skin, fine lines or early signs of aging, acne scars, rosacea, or persistent redness, or skin that has been stressed by environmental factors or previous treatments.
It is also an excellent post-procedure support treatment — for example, after laser treatments — because polynucleotides have anti-inflammatory and wound-healing properties that can support faster, better recovery.
What Does the Treatment Plan Look Like?
A typical Plenhyage treatment course involves 2–4 sessions spaced 3–4 weeks apart. Each session takes approximately 30 minutes. Downtime is minimal — most patients return to normal activities immediately after treatment.
Results appear gradually. By week 4, skin typically becomes more radiant and hydrated. By week 8, improvement in skin tone, texture, and reduction in redness or scarring becomes more noticeable. By month 3, the skin is firmer, smoother, and shows natural rejuvenation. Results vary between individuals depending on skin condition, age, and lifestyle factors.
Frequently Asked Questions
How is Plenhyage different from Rejuran? Both are polynucleotide skin boosters, but they differ in origin and formulation. Rejuran is from Korea with a long-established track record. Plenhyage is from Italy with a higher declared PN concentration (50mg per session), which may deliver more intensive regenerative effects. Both are effective — the choice depends on your specific skin needs and treatment goals.
Is Plenhyage safe? Yes. Plenhyage uses highly purified polynucleotides with a well-established safety profile. Side effects are generally limited to mild redness or small bumps at injection sites, which typically resolve within 24–48 hours.
Can Plenhyage be combined with other treatments? Yes. Plenhyage works well as part of a comprehensive treatment plan. It can be combined with laser treatments, bio-remodelling (like Profhilo), and other aesthetic procedures. Your doctor will advise on the best sequencing and combination for your specific concerns.
Klinik Dr Diana is an authorised clinic for Plenhyage in Malaysia. Our doctors have received professional training from the official distributor. Visit us in Bandar Baru Bangi or Senawang for a personalised skin assessment. Contact us via WhatsApp to book your consultation.